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講演タイトル: Supramolecular Chemistry of Macrocycles Focusing on the Precise Assembly of Molecular Binding Units

講演者: Assist. Prof. Takashi Nakamura
(Department of Chemistry, Institute of Pure and Applied Sciences, University of Tsukuba)

日時: 2025年1月22日 (水) 11:00 – 12:00

場所: 計算科学研究センター 会議室A

言語: 英語

Takashi Nakamura Takashi Nakamura received his Ph.D. in 2013 from the University of Tokyo under the supervision of Prof. Mitsuhiko Shionoya. He joined the laboratory of Prof. Akira Harada at Osaka University as a postdoctoral fellow in 2013. He worked as an assistant professor with Prof. Tatsuya Nabeshima at University of Tsukuba since 2014. Since 2021, he has been a principal investigator of Supramolecular Chemistry Group as a Tsukuba Top Runner Assistant Professor at University of Tsukuba. He received the Chemical Society of Japan Award for Young Chemists in 2020, and the Young Scientists’ Award in the Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, Japan in 2022. Since 2024, he has been leading a JST PRESTO project as its principal investigator. His current research interest is the precise construction of supramolecules and exploration of their functions.

要旨

Natural receptor proteins can selectively bind substrates within a pocket surrounded by multiple amino acid residues. During the recognition process, relatively weak intermolecular interactions, such as hydrogen bonds, act synergistically to achieve high selectivity. In contrast, it has been challenging for synthetic receptors to achieve precise molecular binding by arranging multiple interaction sites in an unsymmetrical manner.

     Our group has developed novel macrocyclic receptors with precise recognition capabilities based on two key strategies: (A) the assembly of metal coordination sites and (B) the desymmetrization of molecular components. Specifically, I will present our recent progress on cyclic oligomers of chelate complexes capable of multipoint coordination, and cyclodextrin derivatives equipped with hydrogen bonding sites such as amide and carboxyl groups.

References

1. (a) Commun. 2017, 8, 129. (b) Chem. Commun. 2019, 55, 2421–2424. (c) Eur. J. Inorg. Chem. 2021, 308–313. (d) Inorg. Chem. 2023, 62, 12886–12894. (e) Chem. Commun. 2024, 60, 1281–1284.
2. (a) Am. Chem. Soc. 2019, 141, 6462–6467. (b) Inorg. Chem. 2019, 58, 7863–7872. (c) Inorg. Chem. 2024, 63, 12697–12702. (d) Chem. Commun. 2025, 61, 921–924.
3. (a) Commun. 2019, 55, 3872–3875. (b) Chem. Lett. 2020, 49, 493–496. (c) Angew. Chem. Int. Ed. 2021, 60, 3080–3086. (d) Chem. Sci. 2025, 16, 171–181.
4. (a) In revision.

世話人: 重田育照、Kowit Hengphasatporn